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phenobarbital will lower the level or effect of olanzapine/samidorphan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Potent CYP3A4 inducers minimize amounts of olanzapine and samidorphan by~50% and ~seventy five% respectively.Liver microsomes are basically subcellular particles, that are isolated from hepa